The Hybaid PCR thermal cycler continues to be the first choice laboratory equipment for small volume laboratories with sub-ambient thermal cycling needs. This dynamic thermal cycler has powerful peltier technology which allows for warming velocity of as quick as 3 degrees Celcius per second and unmatched uniformity throughout the block and incredible accuracy. Each thermal cycler includes a standard heated lid providing users with oil free running. It offers 0.2 milliliter x 24 well or 0.5 milliliter x 20 well thermal cycler block arrangements. With the added benefit of interchangable thermal cycler blocks, laboratories can easily make a switch when testing requirements are altered!
Hybaid, longtime reknown for its Sprint PCR thermal cycler and Express PCR thermal cycler, just started producing its own gradient thermal cycler. The gradient block can be fitted to the PCR Express unit and has the capacity to perform gradient as well as standard cycling. Hybaid's main concern in PCR technology is temperature uniformity. They claim to be the only company that makes built-in tube thermistors to measure true sample temperature. There are dwell time differentials between the annealing temperatures usually when determining gradient protocols for your thermal cycler. Hybaid thermal cyclers aim to overcome this shortcoming with a combination of software solution and their Active Tube temperature control system which observes the temperature of the running sample. The combination of these solutions allow for thermal cycler annealing temperature percision to within 0.5 degrees Celcius.
Video of Thermal Cycler
Material science is constantly noteworthy in regards to the conversations on new technologies. Whether the subject is synthetic polymers, silicates, or Bucky balls, there is seemingly no end to the variety of molecules that can be applied to any given problem. In situations where designers are faced with a lack of technical ideas for improving the mechanical functionality of a particually vexing issue, the often turn to material science to provide a solution. Thermal cycler makers perform testing with a wide array of materials to help increase the accuracy and repeatability of their products. Although most blocks are made from aluminum coated by a hard-anodized surface of corundum crystals, some manufacturers are turning to silver-gold blocks for their accelerated ramping rates. .